Did you know that peripheral neuropathy is one of the most frequent neurological conditions encountered by doctors of all specialties(1)?

In the current context, with an increasingly older population and a progressively higher incidence of diabetes and obesity, the prevalence of peripheral neuropathy is increasing, which is a major public health problem(2).

Peripheral neuropathies are one of the most prevalent neurological disorders in the general population and a frequent reason for medical consultation. Symptoms can range from numbness or tingling to shooting sensations (paresthesia) or muscle weakness. Certain regions of the body can become abnormally sensitive, which can cause an extremely intense or distorted experience of touch (allodynia). In such cases, pain may be felt in response to a stimulus that normally does not cause pain. Its diagnosis and treatment are key to improving the quality of life of patients.

In this Masterclass we invite you to learn in depth about the nerve regeneration process when peripheral neurons suffer an injury and the repairing role of nucleotides in this process..

Peripheral neuropathy develops as a result of damage to the peripheral nervous system that can be caused by traumatic injuries, infections, metabolic problems, hereditary causes, and exposure to toxins. Professor Xavier Navarro will delve into the process of injury and regeneration of the peripheral nervous system, that is, what happens in our body when peripheral neurons suffer injury, Wallerian degeneration and the stages of axonal regeneration.

After reviewing the most physiological part of nerve injury and its regeneration process, Dr. Andrei Danilov will present us with the role of nucleotides in nerve regeneration: how nucleotides intervene in this process, favoring myelin synthesis and restoration. of the nerve impulse thus improving the quality of life of patients. He will tell us about his clinical experience and present the results of the latest published clinical studies with nucleotides.

referencias

1. Watson JC, Dyck PJB. Peripheral Neuropathy: A Practical Approach to Diagnosis and Symptom Management. Mayo Clin Proc 2015;90:940–51. doi:10.1016/j.mayocp.2015.05.004.

2. Barrell K, Smith AG. Peripheral Neuropathy. Med Clin North Am 2019;103:383–97. doi:10.1016/j.mcna.2018.10.006.

3. Negrão L, Almeida P, Alcino S, Duro H, Libório T, Melo Silva U, et al. Effect of the combination of uridine nucleotides, folic acid and vitamin B12 on the clinical expression of peripheral neuropathies. Pain Manag 2014;4:191–6. doi:10.2217/pmt.14.10.

4. Hicks CW, Selvin E. Epidemiology of Peripheral Neuropathy and Lower Extremity Disease in Diabetes. Curr Diab Rep 2019;19:86. doi:10.1007/s11892-019-1212-8.

PROFESSORS

Dr. Andrei Danilov

Neurologist. Department of Neurology Institute of Postgraduate Professional Training of Physicians. Moscow (Russia)

Prof. Xavier Navarro

Dept. of Cell Biology, Physiology and Immunology. Institute of Neuroscience CIBERNED. Universitat Autònoma de Barcelona (Spain)

MASTERCLASS

22nd November 2022
15:00-16:00 UTC/GMT+1

Introduction

Dr. Andrei Danilov

 

How is the process of nerve regeneration carried out in peripheral neuropathies?

Prof. Xavier Navarro

Dept. of Cell Biology, Physiology and Immunology. Institute of Neuroscience CIBERNED. Universitat Autònoma de Barcelona (Spain)

 

Role of nucleotides in nerve regeneration and clinical experience

Dr. Andrei Danilov

Neurologist. Department of Neurology Institute of Postgraduate Professional Training of Physicians. Moscow (Russia))

 

Questions and answers